Sildenafil for the treatment of erectile dysfunction
What is Sildenafil: The drug Sildenafil is considered a selective inhibitor of cyclic adenosine monophosphates with specific characteristics. The drug localizes cyclic nucleotide type 5 cells, responsible for the metabolism of cyclic adenosine monophosphate, which is contained in the vascular walls of the pulmonary biosystem and cavernous tissue of the male sexual organ.
Stopping destructive processes in the prostate biosystem and increasing erectile abilities, the drug restores only response to excitation formed in the cortex of the large hemisphere. In itself, it is not positioned as arousal that can improve the sexual drive or form an interest in the opposite sex in men. The mechanism of action of the drug is based on activation of the relaxing effect that nitric oxide has on the cells. As a result, there is an increase in blood flow in the organoid.
Sildenafil 20mg has a similar effect on the smooth muscle of the pulmonary vascular cells. For patients with pulmonary hypertension (PH), taking it thus relieves the tension of the smooth muscle structure of the body with subsequent dilation of the pulmonary vessels. While the arterioles and veins of other body systems do not respond to the drug.
When using the medication, the occurrence of the following undesirable reactions on the part of
– central nervous system – cerebral vasospasm, lack of sleep, dizziness;
– gastrointestinal organs – diarrhea, flatulence, bloating, pain in the epigastric region, increased fatigue, nausea with vomiting;
– musculoskeletal system – joint and muscle pains, inadequate muscle activity;
– respiratory system – inflammation of the upper respiratory tract, infections and respiratory disorders;
– the visual system – color perception disorder, conjunctival inflammation.
Medical practice has noted a number of accidents when using Sildenafil in the form of flu-like syndrome, vascular smooth muscle relaxation with subsequent lumen dilation, skin rashes, urinary tract infection, prostate problems.
The product is forbidden to take in cases of hypersensitization to some components of the product, lactase deficiency, non-acceptance of lactose, minors. According to some reports, the product is not desirable to use together with ritonavir. It is also not recommended to prescribe the drug to the female sex.
The use of the drug Sildenafil is recommended with caution:
– in Peyronie’s disease, angulation and other pathologies of the genitals;
– bleeding, gastrointestinal ulcers that appear in acute form;
– retinitis pigmentosa, hereditary;
– insufficient work of the heart, pain syndrome in the chest area;
– after a stroke, severe arrhythmia, high blood pressure;
This medicine is not intended for use by women.
Method and peculiarities of use: Capsules are administered in the middle. Basically, the doctor prescribes 0.05 g. Sometimes the rate is adjusted. This takes into account some features of the human body, the tolerability of the product. The amount is allowed to increase to 0.1 g or decrease to 0.025 g. It is not recommended to use the established dosage more than 1 time in 24 hours. In case of insufficient work of the renal organization, which proceeds in a mild or moderate form, a change in the volume of the material is not required.
If, however, the dysfunction is found in a severe form, the amount of medication is lowered to 25 mg. In order to make possible the use of the drug Sildenafil with materials related to α-blockers, hemodynamics must be normalized. The patient’s condition should be monitored by a specialist. Sometimes he has to reduce the dosage of the former. Changing the amount of the substance for people of advanced age is not required.
Compatibility with alcohol: Scientists say that alcoholic products in any form while taking pharmacological drugs are harmful to the body. According to some reports, all the effects that the drug produces, positive and negative, are intensified when using alkaloids. Therefore, the patient may develop unwanted system reactions. Sildenafil refers to chemical materials, so its combination with alcoholic beverages will always cause unwanted symptoms.
The product, which contains alcohol and medicines for potency, leads to the dilation of vascular structures. Their combination causes a man’s head to spin, lowered blood pressure readings, a disorder of the CPS, collapse. Particular attention should be paid to the functioning of the liver. These substances have a negative effect on their activity. If they are injected at the same time, this important organ will be doubly stressed. The consequences may be unpredictable.
The work of the kidneys can also be disturbed. The structure removes from the body the breakdown products of alkaloids and metabolic compounds of the drug. Often such processes lead to the development of complex pathologies. According to some studies, the main substance of the pharmacological product penetrates into the bloodstream much slower when exposed to alcohol than without it. If a patient wants to improve his health, he should clearly follow the doctor’s recommendations and refrain from the use of alcoholic beverages.
What are generic medications? Sildenafil generics
A generic drug is a medicinal product having the same qualitative and quantitative composition of active ingredients (active pharmaceutical substances) and the same dosage form as the original medicinal product.
Generic Sildenafil for men is in quite high demand: it is recommended much more often than other drugs that can also be used to increase sexual activity and enhance erections. The widespread use of this remedy is due to the presence of several important advantages.
1. Complex impact on the male body: substances that are contained in the pills, simultaneously help to establish the sexual function, increase sexual desire and add energy, so that it is possible to significantly prolong sexual intercourse.
2. High efficiency: when taking these pills, you do not need to use additional medications to enhance the effect of “Sildenafil” or to adjust its effect on the male body.
3. quick effect: the active ingredient begins to act already in an hour after taking the pill. Therefore, this drug is excellent for cases when unplanned sex is planned.
4. Long action: if the doctor correctly calculates the dosage, the man will be able to have no problems with an erection within 1 day, and will please his mistress with long intercourse.
5. Cumulative effect: the drug is recommended to take a course. At the same time, users note that gradually the pills begin to act faster, and the resulting effect lasts longer.
6. Low frequency of side effects: as a rule, they are caused by individual intolerance to the drug or by ignoring the doctor’s instructions.
India has a very developed pharmaceutical industry and many generics are produced. Many Indian companies produce popular generics of Viagra, which have been on the market for a long time and have proven themselves:
– Kamagra by Ajanta Pharma,
– Cenforce from Centurion Laboratories,
– Suhagra by Cipla Limited.
You can buy generic Sildenafil at any relevant online store. It will allow for a long time to forget about problems in bed and get real pleasure from sex.
Where to buy Sildenafil online and without a prescription?
Any online pharmacy has 2 important advantages: confidentiality of purchase and the ability to purchase the Sildenafil without a doctor’s prescription. Drugs containing sildenafil are usually sold only with a prescription and after consulting your doctor. So, you get a quality certified drug, thereby guaranteeing excellent results and enjoyment of intimacy.
The price of Sildenafil online is lower than the retail rates in chain pharmacies. In addition, of the advantages to buy Sildenafil, note the high quality of medicines the possibility of the purchase at any time of the day, and prompt delivery. Pharmacies that sell Indian generics, sell generic sildenafil without a prescription and send them in the usual mail.
Why Generic Viagra is cheaper than brand Viagra?
The main advantage of generic Viagra is the price, which is many times less than the original. That’s why cheap Sildenafil is so popular. However, it doesn’t reflect on quality – the cost is less because of lower production costs. Since generics are produced on the basis of a developed and proven technology, without the need for lengthy clinical trials – these steps have already been made by the original manufacturer.
The cost of a generic drug depends on the cost of raw materials, staff salaries, energy and infrastructure costs, etc., which are different in each country and each firm. And they are different in each country and each company, so the price of generic in some cases is 20% and in others is 60% of the original.
Generic Sildenafil vs. Tadalafil
Sildenafil vs. Tadalafil: Sildenafil has a fairly similar price to Tadalafil. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or as products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain, and others. When evaluating metabolism with Sildenafil from India, just like with Tadalafil, we look at which organ is metabolizing and how critical the action is on it.
The risk/benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with mandatory caution in use. In this case, Sildenafil has no risks when used, as well as Tadalafil.
Also in the calculation of safety, we take into account whether only allergic reactions or possible dysfunction of major organs occur. As well as the reversibility of the effects of using Sildenafil and Tadalafil.
Let’s compare contraindications of Sildenafil and Tadalafil. Based on the instructions, the number of contraindications for Sildenafil is quite similar to Tadalafil and is a small number. This is a list of symptoms with syndromes and diseases, various external and internal conditions in which the use of Sildenafil and Tadalafil may be undesirable or unacceptable.
Generic Sildenafil vs. Vardenafil
Sildenafil vs. Vardenafil: To understand whether you can take Vardenafil instead of Sildenafil, you need to compare the effects of both medications. Vardenafil is a potency stimulating substance and is part of many drugs for the treatment of male sexual weakness. The most famous of them is Levitra. All other drugs with this component are its generics. Both drugs, despite their different composition, have the same set of contraindications.
The main feature of vardenafil is that it is allowed to be taken together with alcoholic beverages and heavy food. This does not affect its action in any way. Also, this substance starts working faster than sildenafil. Already after half an hour after taking it, you get a powerful erection.
Another plus in favor of vardenafil is a smaller list of adverse reactions. According to clinical trials, it is clear that they appear only in 3 percent of men. In Sildenafil this figure is much higher – in the range of 10-15%.
It is impossible to unequivocally answer the question of which of these two drugs is better. Each patient is individual and chooses what is suitable for him. But according to doctors, it is better to pay attention to Vardenafil.
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