The substance Tadalafil was developed for the treatment of erectile dysfunction by the pharmaceutical company Icos Corporation, which was later acquired by the American corporation Eli Lilly. The drug entered the market under the brand name “Cialis” and became one of the main competitors of the famous “Viagra” from the pharmaceutical giant Pfizer.
Thus, most clinicians start treatment with oral phosphodiesterase 5 (PDE5) inhibitors that are not effective enough for other oral medications, intracavernous injections, or vacuum devices. Combined treatment is also possible. With the ineffectiveness of such techniques, it is possible to carry out surgical interventions, but the need for them arises less and less.
According to Tadalafil reviews, the drug has a long duration of action, the desired effect is achieved due to the ability of the substance to relax muscles and increase blood flow in the reproductive organs for almost 36 hours. For this reason, the drug has become widespread among the male population of different countries. Buy Tadalafil without a prescription-only at your own risk.
Existing methods and methods of correction in the treatment of erectile dysfunction can be combined into four main groups: psychosexual, drug, vacuum-erection therapy, and surgical treatment. In recent years, researchers’ interest has also begun to attract the possibility of lifestyle adjustments in the treatment of erectile dysfunction.
Over the past decade, significant advances have been made in the treatment of erectile dysfunction, a problem faced by hundreds of millions of men around the world. Several effective oral erectile dysfunction drugs are currently available, belonging to the pharmacological group of type 5 phosphodiesterase inhibitors.
Before discussing the clinical efficacy of Tadalafil, we consider it necessary to briefly dwell on the pharmacodynamic and pharmacokinetic features of type 5 phosphodiesterase inhibitors. The mechanism of action of these drugs is associated with the effect on the system that controls the intracellular concentration of cyclic guanosine monophosphate.
This substance is the most important secondary messenger in various tissues and organs; however, the effect of the discussed drugs is primarily associated with smooth muscle cells. The role of cyclic guanosine monophosphate in the regulation of the functional activity of smooth muscle cells of various organs has been studied in sufficient detail.
It is important to take the drug correctly. The main recommendations of the instructions for using Tadalafil are as follows:
Grapefruit juice weakens the effect of the drug. The medical action is valid for 5-12 hours. When taking the medication before meals, the onset time is reduced to 10 minutes, after meals – it increases to one hour.
It should be noted that under conditions of suppression of type 5 phosphodiesterase activity in cells, where this form of the enzyme is the main one, even a slight increase in guanylate cyclase activity can lead to a sharp increase in the intracellular concentration of cyclic guanosine monophosphate. Despite the high efficacy of the drug, it is not recommended to purchase Tadalafil without a prescription. If you decide to buy the drug, then you can find Tadalafil for sale on the Internet at any resource.
This can cause a pronounced decrease in the tone of smooth muscle cells, which in the case of blood vessels is manifested by a dangerous drop in blood pressure. This circumstance is the reason that the use of nitrates is a strict contraindication to the appointment of phosphodiesterase type 5 inhibitors.
With extreme caution and only if necessary, tadalafil can be used in patients with severe renal impairment.
During treatment with tadalafil in patients with moderate renal impairment, back pain was stronger compared to patients with mild renal insufficiency or healthy volunteers. It is not recommended to buy Tadalafil without a doctor’s prescription, even though the
Tadalafil is taken orally, with or without food, at least 16 minutes before the expected sexual activity, the initial dose is 20 mg. Patients within 36 hours after taking tadalafil can attempt sexual intercourse to establish the optimal response time to taking the drug. By the way, the price of Tadalafil depends on the milligrams and components.
The recommended maximum frequency of admission is 1 time per day. Elderly men do not need to adjust the dose of tadalafil. With mild and moderate liver dysfunction, the maximum dose of the drug is 10 mg 1 time per day.